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Patients with a SULFA allergy should not take MIC B12 injections due to the methionine component [2]

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The BDNF evidence includes preclinical studies showing a 1.4-fold increase in hippocampal BDNF protein and a 3-fold increase in BDNF mRNA expression following a single dose, and a human stroke trial in 110 patients where intranasal Semax produced measurable plasma BDNF elevation associated with improved motor function recovery